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Interactions médicamenteuses

Ergotamine + Miconazole

Gravité: Majeure

Ergotamine and Miconazole: major interaction.

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Résumé

Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.

Ce que signifie cette interaction, en termes simples

Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ergotamine belongs to Central Nervous System; Miconazole belongs to Anti Fungals.

Niveau de preuve: Low

Pourquoi elle survient

CYP3A4 inhibition raising ergotamine exposure (clinically relevant with systemic miconazole)

Conduite à tenir

Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ergotamine with Miconazole?

MediHelp rates the interaction as major. Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.

How serious is the interaction between Ergotamine and Miconazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.

What other medicines interact with Miconazole?

MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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