Référentiel des médicaments
Miconazole
Miconazole is a medicine in the class anti fungals. It is used for oropharyngeal candidiasis.
- Classe médicamenteuse: Anti Fungals
- Indications: oropharyngeal candidiasis
Dernière mise à jour Sources: US FDA label, UK SmPC, Base de donnees publique des medicaments (France), ANSM Base de donnees publique des medicaments (RCP, French)
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L'essentiel
- Classe médicamenteuse
- Anti Fungals
- Formes courantes
- crème, poudre, gel, inhalateur, pommade, solution
- Dosages courants
- 2 g/100 g, 2%, 20 mg/g
- Interactions connues
- 50 (Majeure: 12 · Modérée: 24 · Mineure: 14)
- Noms commerciaux
- 232
- Pays et marchés
- 5
Indications
Mécanisme d'action
Azole antifungal agent; inhibits enzyme cytochrome P450 14-alpha-demethylase resulting in ergosterol synthesis inhibition
Posologie adulte habituelle (résumé de la notice)
Oropharyngeal Candidiasis: Apply 50 mg buccal tab to gum region qDay for 14 consecutive days
Grossesse et allaitement
- Grossesse
- Unknown Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush).
- Allaitement
- Safe No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
Effets indésirables signalés
- Irritation
- Diarrhea
- Nausea
- Allergic contact dermatitis
- Burning
Contre-indications
- Hypersensitivity to drug, milk protein concentrate, or other excipients
Précautions particulières
- Miconazole is systemically absorbed and inhibits CYP2C9 and CYP3A4, prolonging the effect of warfarin; bleeding events, some fatal, have been reported with oral gel. Monitor the anticoagulant effect carefully if coumarin anticoagulants are used concomitantly.
- Choking risk in infants and young children (4 months to 2 years): do not apply the gel to the back of the throat, divide each dose into small portions and observe the patient. Do not apply it to a nipple for infant administration.
- Severe hypersensitivity reactions including anaphylaxis and angioedema have been reported; stop treatment if hypersensitivity or irritation occurs.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (50)
- Cabazitaxel + Miconazole Major
- Dihydroergotamine + Miconazole Major
- Dihydroergotamine intranasal + Miconazole Major
- Ergotamine + Miconazole Major
- Glyburide + Miconazole Major
- Lovastatin + Miconazole Major
- Methadone + Miconazole Major
- Miconazole + Pimozide Major
- Miconazole + Ribociclib Major
- Miconazole + Simvastatin Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Autres médicaments de cette classe
Questions fréquentes
What is Miconazole used for?
Miconazole is a medicine in the class anti fungals. It is used for Oropharyngeal candidiasis, Tinea, Vulvovaginal candidiasis.
What side effects have been reported with Miconazole?
Irritation, Diarrhea, Nausea, Allergic contact dermatitis, Burning.
Can Miconazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush). Breastfeeding: Safe. No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
What does Miconazole interact with?
MediHelp lists 50 known interactions for Miconazole. Major: 12 · Moderate: 24 · Minor: 14. The most serious include Cabazitaxel, Dihydroergotamine, Dihydroergotamine intranasal.
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