Interactions médicamenteuses
Escitalopram + Methylene blue
Gravité: Contre-indiquée
Escitalopram and Methylene blue: contraindicated interaction.
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Résumé
Methylene blue inhibits monoamine oxidase A, and combining it with an SSRI can cause serotonin syndrome, which has been reported with intravenous use. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.
Ce que signifie cette interaction, en termes simples
Escitalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Methylene blue inhibits MAO-A, raising serotonin levels on top of SSRI reuptake blockade.
Conduite à tenir
Avoid the combination in elective settings. If methylene blue is urgently needed, stop escitalopram and monitor for serotonin toxicity for up to 2 weeks or 24 hours after the last methylene blue dose, whichever comes first.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Escitalopram
- Cisapride + Escitalopram Contre-indiquée
- Citalopram + Escitalopram Contre-indiquée
- Escitalopram + Isocarboxazid Contre-indiquée
- Escitalopram + Phenelzine Contre-indiquée
- Escitalopram + Pimozide Contre-indiquée
- Escitalopram + Procarbazine Contre-indiquée
Questions fréquentes
Can I take Escitalopram with Methylene blue?
MediHelp rates the interaction as contraindicated. Escitalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, and combining it with an SSRI can cause serotonin syndrome, which has been reported with intravenous use. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.
How serious is the interaction between Escitalopram and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in elective settings. If methylene blue is urgently needed, stop escitalopram and monitor for serotonin toxicity for up to 2 weeks or 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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