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Interactions médicamenteuses

Escitalopram + Isocarboxazid

Gravité: Contre-indiquée

Escitalopram and Isocarboxazid: contraindicated interaction.

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Résumé

Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

Ce que signifie cette interaction, en termes simples

Escitalopram and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Escitalopram belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of monoamine oxidase combined with an SSRI activity leading to excess serotonergic stimulation

Conduite à tenir

Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Escitalopram with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Escitalopram and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

How serious is the interaction between Escitalopram and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.

What other medicines interact with Escitalopram?

MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Methylene blue. The full list is on the Escitalopram page.

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