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Interactions médicamenteuses

Etanercept + Measles vaccine

Gravité: Contre-indiquée

Etanercept and Measles vaccine: contraindicated interaction.

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Résumé

Measles vaccine is live attenuated, and TNF blockade may allow uncontrolled vaccine virus replication. Disseminated vaccine-strain infection is a theoretical risk. Immune response may also be reduced.

Ce que signifie cette interaction, en termes simples

Etanercept and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Niveau de preuve: Moderate

Pourquoi elle survient

Immunosuppression from TNF inhibition reduces control of live attenuated virus replication.

Conduite à tenir

Avoid live measles vaccine during etanercept therapy. Vaccinate at least 4 weeks before starting treatment where possible, or after an adequate washout, and consider immunoglobulin if exposed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Etanercept with Measles vaccine?

MediHelp rates the interaction as contraindicated. Etanercept and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine is live attenuated, and TNF blockade may allow uncontrolled vaccine virus replication. Disseminated vaccine-strain infection is a theoretical risk. Immune response may also be reduced.

How serious is the interaction between Etanercept and Measles vaccine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live measles vaccine during etanercept therapy. Vaccinate at least 4 weeks before starting treatment where possible, or after an adequate washout, and consider immunoglobulin if exposed.

What other medicines interact with Etanercept?

MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.

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