Interactions médicamenteuses
Etodolac + Ketorolac intranasal
Gravité: Contre-indiquée
Etodolac and Ketorolac intranasal: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Using etodolac with intranasal ketorolac gives duplicate NSAID therapy, increasing the risk of gastrointestinal bleeding or ulceration, renal impairment and cardiovascular events. Intranasal ketorolac is systemically absorbed and carries the same prohibition on concurrent NSAIDs as the oral form.
Ce que signifie cette interaction, en termes simples
Etodolac and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
Conduite à tenir
Avoid the combination; use a single NSAID. Stop etodolac before starting ketorolac, or choose a non-NSAID analgesic.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Etodolac
- Etodolac + Ketorolac Contre-indiquée
- Aceclofenac + Etodolac Majeure
- Acemetacin + Etodolac Majeure
- Acetylsalicylic acid + Etodolac Majeure
- Alteplase + Etodolac Majeure
- Amlodipine-olmesartan-hydrochlorothiazide + Etodolac Majeure
Questions fréquentes
Can I take Etodolac with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Etodolac and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Using etodolac with intranasal ketorolac gives duplicate NSAID therapy, increasing the risk of gastrointestinal bleeding or ulceration, renal impairment and cardiovascular events. Intranasal ketorolac is systemically absorbed and carries the same prohibition on concurrent NSAIDs as the oral form.
How serious is the interaction between Etodolac and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a single NSAID. Stop etodolac before starting ketorolac, or choose a non-NSAID analgesic.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Etodolac page.
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