Interactions médicamenteuses
Everolimus + Measles vaccine
Gravité: Contre-indiquée
Everolimus and Measles vaccine: contraindicated interaction.
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Résumé
Measles vaccine is live attenuated, and in a patient immunosuppressed by everolimus the vaccine virus may replicate unchecked and cause disseminated disease. The immune response may also be inadequate.
Ce que signifie cette interaction, en termes simples
Everolimus and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Immunosuppression from mTOR inhibition impairs control of live attenuated virus and reduces vaccine response.
Conduite à tenir
Avoid live vaccines during everolimus therapy and for a period after stopping. Update live vaccines before starting treatment when possible.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Everolimus
- Bcg vaccine live + Everolimus Contre-indiquée
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Everolimus + Levoketoconazole Contre-indiquée
- Everolimus + Measles mumps and rubella vaccine live Contre-indiquée
- Everolimus + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Everolimus + Ritonavir Contre-indiquée
Questions fréquentes
Can I take Everolimus with Measles vaccine?
MediHelp rates the interaction as contraindicated. Everolimus and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine is live attenuated, and in a patient immunosuppressed by everolimus the vaccine virus may replicate unchecked and cause disseminated disease. The immune response may also be inadequate.
How serious is the interaction between Everolimus and Measles vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during everolimus therapy and for a period after stopping. Update live vaccines before starting treatment when possible.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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