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Interactions médicamenteuses

Everolimus + Ritonavir

Gravité: Contre-indiquée

Everolimus and Ritonavir: contraindicated interaction.

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Résumé

Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can markedly raise everolimus exposure. This increases the risk of mTOR inhibitor toxicity such as infections, myelosuppression, hyperglycemia, hyperlipidemia, stomatitis and pneumonitis.

Ce que signifie cette interaction, en termes simples

Everolimus and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Everolimus belongs to Oncology; Ritonavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Ritonavir inhibits intestinal and hepatic CYP3A4 and P-glycoprotein, reducing everolimus clearance and increasing absorption.

Conduite à tenir

Avoid concomitant use and select an antiretroviral regimen without strong CYP3A4 inhibition. If unavoidable, use only with specialist oversight, major everolimus dose reduction and therapeutic drug monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Everolimus with Ritonavir?

MediHelp rates the interaction as contraindicated. Everolimus and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can markedly raise everolimus exposure. This increases the risk of mTOR inhibitor toxicity such as infections, myelosuppression, hyperglycemia, hyperlipidemia, stomatitis and pneumonitis.

How serious is the interaction between Everolimus and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an antiretroviral regimen without strong CYP3A4 inhibition. If unavoidable, use only with specialist oversight, major everolimus dose reduction and therapeutic drug monitoring.

What other medicines interact with Everolimus?

MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.

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