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Interactions médicamenteuses

Fentanyl + Pheniramine

Gravité: Modérée

Fentanyl and Pheniramine: moderate interaction.

Dernière mise à jour

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Résumé

Pheniramine is a sedating first-generation antihistamine, and with fentanyl it increases drowsiness and impairs psychomotor performance. Respiratory depression is possible, especially in older or frail patients.

Ce que signifie cette interaction, en termes simples

Fentanyl and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Fentanyl belongs to Musculoskeletal; Pheniramine belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive CNS depression via histamine H1 blockade and opioid receptor agonism.

Conduite à tenir

Prefer a non-sedating antihistamine when an antihistamine is needed. If pheniramine is used, monitor for excess sedation and warn against driving and alcohol.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fentanyl with Pheniramine?

MediHelp rates the interaction as moderate. Fentanyl and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a sedating first-generation antihistamine, and with fentanyl it increases drowsiness and impairs psychomotor performance. Respiratory depression is possible, especially in older or frail patients.

How serious is the interaction between Fentanyl and Pheniramine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine when an antihistamine is needed. If pheniramine is used, monitor for excess sedation and warn against driving and alcohol.

What other medicines interact with Fentanyl?

MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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