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Interactions médicamenteuses

Fesoterodine + Thioridazine

Gravité: Majeure

Fesoterodine and Thioridazine: major interaction.

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Résumé

Thioridazine has strong anticholinergic activity, so combined use markedly increases risk of dry mouth, constipation, urinary retention, confusion and tachycardia. Thioridazine is also a CYP2D6 substrate and inhibitor with a risk of QT prolongation.

Ce que signifie cette interaction, en termes simples

Fesoterodine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fesoterodine belongs to Genitourinary; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive antimuscarinic effects, with thioridazine's CYP2D6 inhibition potentially raising fesoterodine metabolite levels.

Conduite à tenir

Avoid the combination where possible, particularly in elderly patients. If unavoidable, monitor for anticholinergic toxicity and ECG changes.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fesoterodine with Thioridazine?

MediHelp rates the interaction as major. Fesoterodine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine has strong anticholinergic activity, so combined use markedly increases risk of dry mouth, constipation, urinary retention, confusion and tachycardia. Thioridazine is also a CYP2D6 substrate and inhibitor with a risk of QT prolongation.

How serious is the interaction between Fesoterodine and Thioridazine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in elderly patients. If unavoidable, monitor for anticholinergic toxicity and ECG changes.

What other medicines interact with Fesoterodine?

MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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