Interactions médicamenteuses
Fesoterodine + Tolterodine
Gravité: Majeure
Fesoterodine and Tolterodine: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Fesoterodine is a prodrug of 5-hydroxymethyl tolterodine, which is the main active metabolite of tolterodine. Taking both gives duplicate antimuscarinic therapy and no added benefit. Anticholinergic adverse effects such as dry mouth, constipation, urinary retention and QT effects become more likely.
Ce que signifie cette interaction, en termes simples
Fesoterodine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fesoterodine belongs to Genitourinary; Tolterodine belongs to Genitourinary.
Pourquoi elle survient
Therapeutic duplication, because both drugs yield the same active antimuscarinic metabolite.
Conduite à tenir
Do not use the two together. Choose one agent and titrate it, or switch to another class such as a beta-3 agonist if the response is inadequate.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Fesoterodine et Tolterodine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Tolterodine
Autres interactions de Fesoterodine
- Bethanechol + Fesoterodine Majeure
- Clozapine + Fesoterodine Majeure
- Fesoterodine + Levoketoconazole Majeure
- Fesoterodine + Pramlintide Majeure
- Fesoterodine + Thioridazine Majeure
- Abobotulinumtoxina + Fesoterodine Modérée
Questions fréquentes
Can I take Fesoterodine with Tolterodine?
MediHelp rates the interaction as major. Fesoterodine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fesoterodine is a prodrug of 5-hydroxymethyl tolterodine, which is the main active metabolite of tolterodine. Taking both gives duplicate antimuscarinic therapy and no added benefit. Anticholinergic adverse effects such as dry mouth, constipation, urinary retention and QT effects become more likely.
How serious is the interaction between Fesoterodine and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. Choose one agent and titrate it, or switch to another class such as a beta-3 agonist if the response is inadequate.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
