Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Fluconazole + Selumetinib

Gravité: Majeure

Fluconazole and Selumetinib: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.

Ce que signifie cette interaction, en termes simples

Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fluconazole belongs to Anti Fungals; Selumetinib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Fluconazole inhibits CYP3A4 metabolism of selumetinib.

Conduite à tenir

Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Fluconazole et Selumetinib, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.

Questions fréquentes

Can I take Fluconazole with Selumetinib?

MediHelp rates the interaction as major. Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.

How serious is the interaction between Fluconazole and Selumetinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.

What other medicines interact with Fluconazole?

MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter