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Interactions médicamenteuses

Dihydroergotamine + Fluconazole

Gravité: Contre-indiquée

Dihydroergotamine and Fluconazole: contraindicated interaction.

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Résumé

Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP3A4-mediated dihydroergotamine metabolism by fluconazole.

Conduite à tenir

Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Fluconazole?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.

How serious is the interaction between Dihydroergotamine and Fluconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.

What other medicines interact with Fluconazole?

MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dofetilide, Dronedarone. The full list is on the Fluconazole page.

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