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Interactions médicamenteuses

Frovatriptan + Sumatriptan

Gravité: Contre-indiquée

Frovatriptan and Sumatriptan: contraindicated interaction.

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Résumé

Frovatriptan and sumatriptan are both 5-HT1B/1D agonists that constrict cranial and coronary vessels. Taken close together, the vasoconstriction is additive and may cause coronary or peripheral vasospasm.

Ce que signifie cette interaction, en termes simples

Frovatriptan and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Frovatriptan belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive 5-HT1B/1D-mediated vasoconstriction

Conduite à tenir

Do not use frovatriptan and sumatriptan within 24 hours of each other; choose a single triptan per attack.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Frovatriptan with Sumatriptan?

MediHelp rates the interaction as contraindicated. Frovatriptan and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Frovatriptan and sumatriptan are both 5-HT1B/1D agonists that constrict cranial and coronary vessels. Taken close together, the vasoconstriction is additive and may cause coronary or peripheral vasospasm.

How serious is the interaction between Frovatriptan and Sumatriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use frovatriptan and sumatriptan within 24 hours of each other; choose a single triptan per attack.

What other medicines interact with Sumatriptan?

MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.

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