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Interactions médicamenteuses

Dihydroergotamine + Sumatriptan

Gravité: Contre-indiquée

Dihydroergotamine and Sumatriptan: contraindicated interaction.

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Résumé

Both drugs constrict blood vessels, and combined use can produce additive prolonged vasospasm with risk of coronary or peripheral ischemia. Labeling prohibits use of triptans and ergot derivatives within 24 hours of each other.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive vasoconstriction via 5-HT1B/1D agonism by sumatriptan and serotonergic and adrenergic vasoconstriction by dihydroergotamine.

Conduite à tenir

Do not use within 24 hours of each other. Choose one agent for each migraine episode and observe the timing interval.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Sumatriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs constrict blood vessels, and combined use can produce additive prolonged vasospasm with risk of coronary or peripheral ischemia. Labeling prohibits use of triptans and ergot derivatives within 24 hours of each other.

How serious is the interaction between Dihydroergotamine and Sumatriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other. Choose one agent for each migraine episode and observe the timing interval.

What other medicines interact with Sumatriptan?

MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Sumatriptan page.

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