Interactions médicamenteuses
Ganciclovir + Imipenem / cilastatin / relebactam
Gravité: Majeure
Ganciclovir and Imipenem / cilastatin / relebactam: major interaction.
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Résumé
Imipenem-containing products can lower the seizure threshold, and seizures have been described when imipenem/cilastatin was given with ganciclovir. The same concern is expected with the relebactam combination because it contains imipenem.
Ce que signifie cette interaction, en termes simples
Ganciclovir and Imipenem / cilastatin / relebactam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Probable additive lowering of the seizure threshold, extrapolated from imipenem; the exact mechanism is not established.
Conduite à tenir
Avoid the combination unless there is no suitable alternative antibiotic. If used, dose both drugs for renal function and monitor for neurological symptoms.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ganciclovir
- Bacitracin + Ganciclovir Majeure
- Cilastatin-imipenem + Ganciclovir Majeure
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- Ganciclovir + Imipenem / cilastatin Majeure
- Ganciclovir + Liposomal doxorubicin Majeure
- Ganciclovir + Maribavir Majeure
Questions fréquentes
Can I take Ganciclovir with Imipenem / cilastatin / relebactam?
MediHelp rates the interaction as major. Ganciclovir and Imipenem / cilastatin / relebactam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipenem-containing products can lower the seizure threshold, and seizures have been described when imipenem/cilastatin was given with ganciclovir. The same concern is expected with the relebactam combination because it contains imipenem.
How serious is the interaction between Ganciclovir and Imipenem / cilastatin / relebactam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless there is no suitable alternative antibiotic. If used, dose both drugs for renal function and monitor for neurological symptoms.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
