Interactions médicamenteuses
Didanosine + Ganciclovir
Gravité: Majeure
Didanosine and Ganciclovir: major interaction.
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Résumé
Ganciclovir increases didanosine exposure, which can heighten didanosine toxicities such as pancreatitis, peripheral neuropathy and lactic acidosis. Both drugs can also cause bone marrow or other toxicities, complicating the picture.
Ce que signifie cette interaction, en termes simples
Didanosine and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Didanosine belongs to Anti Virals; Ganciclovir belongs to Anti Virals.
Pourquoi elle survient
Ganciclovir reduces didanosine clearance, probably via competition for renal elimination, with overlapping toxicities.
Conduite à tenir
Avoid the combination if possible; if needed, consider reducing the didanosine dose and monitor for pancreatitis, neuropathy, lactate and blood counts.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ganciclovir
Autres interactions de Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contre-indiquée
- Didanosine + Hydroxycarbamide Contre-indiquée
- Didanosine + Hydroxyurea Contre-indiquée
- Didanosine + Ribavirin Contre-indiquée
- Didanosine + Stavudine Contre-indiquée
- Allopurinol + Didanosine Majeure
Questions fréquentes
Can I take Didanosine with Ganciclovir?
MediHelp rates the interaction as major. Didanosine and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ganciclovir increases didanosine exposure, which can heighten didanosine toxicities such as pancreatitis, peripheral neuropathy and lactic acidosis. Both drugs can also cause bone marrow or other toxicities, complicating the picture.
How serious is the interaction between Didanosine and Ganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, consider reducing the didanosine dose and monitor for pancreatitis, neuropathy, lactate and blood counts.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Imipenem / cilastatin. The full list is on the Ganciclovir page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
