Interactions médicamenteuses
Gefitinib + Rifampicin
Gravité: Majeure
Gefitinib and Rifampicin: major interaction.
Dernière mise à jour
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Résumé
Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
Ce que signifie cette interaction, en termes simples
Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Pourquoi elle survient
Induction of CYP3A4 by rifampicin increases the metabolic clearance of gefitinib.
Conduite à tenir
Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Gefitinib
- Apalutamide + Gefitinib Majeure
- Carbamazepine + Gefitinib Majeure
- Dexlansoprazole + Gefitinib Majeure
- Esomeprazole + Gefitinib Majeure
- Gefitinib + Lansoprazole Majeure
- Gefitinib + Omeprazole Majeure
Autres interactions de Rifampicin
- Cabotegravir + Rifampicin Contre-indiquée
- Delamanid + Rifampicin Contre-indiquée
- Doravirine + Rifampicin Contre-indiquée
- Ensitrelvir + Rifampicin Contre-indiquée
- Fostemsavir + Rifampicin Contre-indiquée
- Isavuconazole + Rifampicin Contre-indiquée
Questions fréquentes
Can I take Gefitinib with Rifampicin?
MediHelp rates the interaction as major. Gefitinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly lowers gefitinib plasma concentrations through enzyme induction. Subtherapeutic exposure may lead to loss of tumour control.
How serious is the interaction between Gefitinib and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If rifampicin is necessary, raise gefitinib to 500 mg daily as per labeling and return to 250 mg after the inducer has been stopped for about 7 days.
What other medicines interact with Gefitinib?
MediHelp also lists interactions of Gefitinib with, for example, Apalutamide, Carbamazepine, Dexlansoprazole. The full list is on the Gefitinib page.
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