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Interactions médicamenteuses

Doravirine + Rifampicin

Gravité: Contre-indiquée

Doravirine and Rifampicin: contraindicated interaction.

Dernière mise à jour

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Résumé

Rifampicin markedly reduces doravirine concentrations, which may lead to loss of antiviral efficacy and resistance. The combination is contraindicated in labeling.

Ce que signifie cette interaction, en termes simples

Doravirine and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Doravirine belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Rifampicin strongly induces CYP3A4, increasing doravirine clearance.

Conduite à tenir

Do not use together. Use an alternative TB regimen, such as rifabutin with a doravirine dose increase per labeling, or change the antiretroviral regimen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doravirine with Rifampicin?

MediHelp rates the interaction as contraindicated. Doravirine and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin markedly reduces doravirine concentrations, which may lead to loss of antiviral efficacy and resistance. The combination is contraindicated in labeling.

How serious is the interaction between Doravirine and Rifampicin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use an alternative TB regimen, such as rifabutin with a doravirine dose increase per labeling, or change the antiretroviral regimen.

What other medicines interact with Doravirine?

MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.

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