Interactions médicamenteuses
Glucarpidase + Methotrexate
Gravité: Modérée
Glucarpidase and Methotrexate: moderate interaction.
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Résumé
Glucarpidase rapidly breaks methotrexate down into DAMPA, which cross-reacts in immunoassays and falsely elevates measured methotrexate. This can lead to misjudged rescue dosing for roughly two days.
Ce que signifie cette interaction, en termes simples
Glucarpidase and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucarpidase belongs to Miscellaneous; Methotrexate belongs to Oncology.
Pourquoi elle survient
Enzymatic cleavage of methotrexate to DAMPA and glutamate lowers true levels while DAMPA interferes with immunoassays.
Conduite à tenir
Measure methotrexate with a chromatographic method (e.g., HPLC) for at least 48 hours after glucarpidase. If only immunoassay is available, interpret results with caution.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Glucarpidase
- Glucarpidase + Leucovorin Majeure
- Folic acid + Glucarpidase Modérée
- Glucarpidase + Pemetrexed Mineure
- Glucarpidase + Pralatrexate Mineure
Autres interactions de Methotrexate
- Acitretin + Methotrexate Contre-indiquée
- Adenovirus types 4 and 7 live + Methotrexate Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contre-indiquée
- Ketorolac + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine live + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine + Methotrexate Contre-indiquée
Questions fréquentes
Can I take Glucarpidase with Methotrexate?
MediHelp rates the interaction as moderate. Glucarpidase and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucarpidase rapidly breaks methotrexate down into DAMPA, which cross-reacts in immunoassays and falsely elevates measured methotrexate. This can lead to misjudged rescue dosing for roughly two days.
How serious is the interaction between Glucarpidase and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure methotrexate with a chromatographic method (e.g., HPLC) for at least 48 hours after glucarpidase. If only immunoassay is available, interpret results with caution.
What other medicines interact with Glucarpidase?
MediHelp also lists interactions of Glucarpidase with, for example, Leucovorin, Folic acid, Pemetrexed. The full list is on the Glucarpidase page.
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