Interactions médicamenteuses
Glucarpidase + Leucovorin
Gravité: Majeure
Glucarpidase and Leucovorin: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Glucarpidase can hydrolyze leucovorin and its active metabolite, reducing rescue effect if given close together. Reduced rescue may worsen methotrexate toxicity.
Ce que signifie cette interaction, en termes simples
Glucarpidase and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glucarpidase belongs to Miscellaneous; Leucovorin belongs to Miscellaneous.
Pourquoi elle survient
Glucarpidase is a carboxypeptidase that cleaves folate analogs, including leucovorin.
Conduite à tenir
Do not give leucovorin within 2 hours before or after glucarpidase. Dose leucovorin on the basis of the methotrexate concentration measured by a chromatographic method.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Glucarpidase
- Folic acid + Glucarpidase Modérée
- Glucarpidase + Methotrexate Modérée
- Glucarpidase + Pemetrexed Mineure
- Glucarpidase + Pralatrexate Mineure
Autres interactions de Leucovorin
- Capecitabine + Leucovorin Majeure
- Fluorouracil + Leucovorin Majeure
- Leucovorin + Phenobarbitone Modérée
- Leucovorin + Phenytoin Modérée
Questions fréquentes
Can I take Glucarpidase with Leucovorin?
MediHelp rates the interaction as major. Glucarpidase and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glucarpidase can hydrolyze leucovorin and its active metabolite, reducing rescue effect if given close together. Reduced rescue may worsen methotrexate toxicity.
How serious is the interaction between Glucarpidase and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give leucovorin within 2 hours before or after glucarpidase. Dose leucovorin on the basis of the methotrexate concentration measured by a chromatographic method.
What other medicines interact with Glucarpidase?
MediHelp also lists interactions of Glucarpidase with, for example, Folic acid, Methotrexate, Pemetrexed. The full list is on the Glucarpidase page.
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