Interactions médicamenteuses
Hydrochlorothiazide-lisinopril + Sacubitril / valsartan
Gravité: Contre-indiquée
Hydrochlorothiazide-lisinopril and Sacubitril / valsartan: contraindicated interaction.
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Résumé
Combining lisinopril with sacubitril/valsartan is contraindicated because of angioedema risk. Dual RAAS blockade also increases hypotension, hyperkalemia and renal dysfunction. Hydrochlorothiazide adds volume depletion and further hypotension risk.
Ce que signifie cette interaction, en termes simples
Hydrochlorothiazide-lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
ACE inhibition plus neprilysin inhibition raises bradykinin levels, causing angioedema, and dual RAAS blockade compounds hypotension and hyperkalemia.
Conduite à tenir
Do not use together. Allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and vice versa.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contre-indiquée
- Amifostine + Hydrochlorothiazide-lisinopril Majeure
- Amiloride + Hydrochlorothiazide-lisinopril Majeure
- Benazepril + Hydrochlorothiazide-lisinopril Majeure
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Majeure
- Candesartan + Hydrochlorothiazide-lisinopril Majeure
Questions fréquentes
Can I take Hydrochlorothiazide-lisinopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Hydrochlorothiazide-lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining lisinopril with sacubitril/valsartan is contraindicated because of angioedema risk. Dual RAAS blockade also increases hypotension, hyperkalemia and renal dysfunction. Hydrochlorothiazide adds volume depletion and further hypotension risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and vice versa.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Amifostine, Amiloride. The full list is on the Hydrochlorothiazide-lisinopril page.
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