Interactions médicamenteuses
Bendroflumethiazide + Hydrochlorothiazide-lisinopril
Gravité: Majeure
Bendroflumethiazide and Hydrochlorothiazide-lisinopril: major interaction.
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Résumé
Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
Ce que signifie cette interaction, en termes simples
Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss and volume depletion.
Conduite à tenir
Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contre-indiquée
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contre-indiquée
- Amifostine + Hydrochlorothiazide-lisinopril Majeure
- Amiloride + Hydrochlorothiazide-lisinopril Majeure
- Benazepril + Hydrochlorothiazide-lisinopril Majeure
- Candesartan + Hydrochlorothiazide-lisinopril Majeure
Questions fréquentes
Can I take Bendroflumethiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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