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Interactions médicamenteuses

Benazepril + Hydrochlorothiazide-lisinopril

Gravité: Majeure

Benazepril and Hydrochlorothiazide-lisinopril: major interaction.

Dernière mise à jour

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Résumé

Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.

Ce que signifie cette interaction, en termes simples

Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Benazepril belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Therapeutic duplication causing excessive ACE inhibition and reduced angiotensin II and aldosterone.

Conduite à tenir

Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Benazepril with Hydrochlorothiazide-lisinopril?

MediHelp rates the interaction as major. Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.

How serious is the interaction between Benazepril and Hydrochlorothiazide-lisinopril?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.

What other medicines interact with Hydrochlorothiazide-lisinopril?

MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.

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