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Interactions médicamenteuses

Hydrocodone + Phenelzine

Gravité: Contre-indiquée

Hydrocodone and Phenelzine: contraindicated interaction.

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Résumé

MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.

Ce que signifie cette interaction, en termes simples

Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydrocodone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of monoamine oxidase raises serotonergic and noradrenergic activity, with possible potentiation of opioid CNS effects.

Conduite à tenir

Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Hydrocodone with Phenelzine?

MediHelp rates the interaction as contraindicated. Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.

How serious is the interaction between Hydrocodone and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.

What other medicines interact with Hydrocodone?

MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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