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Interactions médicamenteuses

Hydrocodone + Isocarboxazid

Gravité: Contre-indiquée

Hydrocodone and Isocarboxazid: contraindicated interaction.

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Résumé

MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.

Ce que signifie cette interaction, en termes simples

Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydrocodone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Nonselective MAO inhibition raises serotonergic and noradrenergic activity and may alter opioid effects, causing serotonin toxicity or CNS depression.

Conduite à tenir

Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Hydrocodone with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.

How serious is the interaction between Hydrocodone and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.

What other medicines interact with Hydrocodone?

MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydrocodone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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