Interactions médicamenteuses
Bupropion-naltrexone + Hydrocodone
Gravité: Contre-indiquée
Bupropion-naltrexone and Hydrocodone: contraindicated interaction.
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Résumé
Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
Ce que signifie cette interaction, en termes simples
Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.
Pourquoi elle survient
Naltrexone competitively antagonizes opioid receptors; bupropion inhibits CYP2D6 and lowers seizure threshold.
Conduite à tenir
Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Bupropion-naltrexone
- Bupropion-naltrexone + Hydromorphone Contre-indiquée
- Bupropion-naltrexone + Isocarboxazid Contre-indiquée
- Bupropion-naltrexone + Linezolid Contre-indiquée
- Bupropion-naltrexone + Phenelzine Contre-indiquée
- Bupropion-naltrexone + Rasagiline Contre-indiquée
- Bupropion-naltrexone + Selegiline Contre-indiquée
Autres interactions de Hydrocodone
- Alvimopan + Hydrocodone Contre-indiquée
- Hydrocodone + Isocarboxazid Contre-indiquée
- Hydrocodone + Olanzapine / samidorphan Contre-indiquée
- Hydrocodone + Phenelzine Contre-indiquée
- Alfentanil + Hydrocodone Majeure
- Alprazolam + Hydrocodone Majeure
Questions fréquentes
Can I take Bupropion-naltrexone with Hydrocodone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
How serious is the interaction between Bupropion-naltrexone and Hydrocodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydromorphone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
