Interactions médicamenteuses
Hydromorphone + Olanzapine / samidorphan
Gravité: Contre-indiquée
Hydromorphone and Olanzapine / samidorphan: contraindicated interaction.
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Résumé
Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
Ce que signifie cette interaction, en termes simples
Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Pharmacodynamic antagonism at opioid receptors by samidorphan.
Conduite à tenir
Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Hydromorphone
- Alvimopan + Hydromorphone Contre-indiquée
- Bupropion-naltrexone + Hydromorphone Contre-indiquée
- Hydromorphone + Isocarboxazid Contre-indiquée
- Hydromorphone + Phenelzine Contre-indiquée
- Hydromorphone + Tranylcypromine Contre-indiquée
- Alfentanil + Hydromorphone Majeure
Questions fréquentes
Can I take Hydromorphone with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Hydromorphone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks hydromorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Pain control may be lost.
How serious is the interaction between Hydromorphone and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Choose another antipsychotic if opioid therapy is needed.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
