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Interactions médicamenteuses

Hydromorphone + Phenelzine

Gravité: Contre-indiquée

Hydromorphone and Phenelzine: contraindicated interaction.

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Résumé

Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.

Ce que signifie cette interaction, en termes simples

Hydromorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydromorphone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.

Conduite à tenir

Avoid concurrent use and wait at least 14 days after stopping phenelzine before giving hydromorphone. Select an alternative analgesic if the patient is on an MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Hydromorphone with Phenelzine?

MediHelp rates the interaction as contraindicated. Hydromorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with nonselective MAOIs have caused severe reactions including hypotension, hyperthermia, respiratory depression and coma. Hydromorphone labeling advises against use during or within 14 days of MAOI therapy.

How serious is the interaction between Hydromorphone and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and wait at least 14 days after stopping phenelzine before giving hydromorphone. Select an alternative analgesic if the patient is on an MAOI.

What other medicines interact with Hydromorphone?

MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.

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