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Interactions médicamenteuses

Hydromorphone + Isocarboxazid

Gravité: Contre-indiquée

Hydromorphone and Isocarboxazid: contraindicated interaction.

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Résumé

Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.

Ce que signifie cette interaction, en termes simples

Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Hydromorphone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.

Conduite à tenir

Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Hydromorphone with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.

How serious is the interaction between Hydromorphone and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.

What other medicines interact with Hydromorphone?

MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydromorphone page.

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