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Interactions médicamenteuses

Ibutilide + Mefloquine

Gravité: Contre-indiquée

Ibutilide and Mefloquine: contraindicated interaction.

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Résumé

Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Mefloquine can add to repolarization delay, so the combination increases the risk of life-threatening arrhythmia.

Ce que signifie cette interaction, en termes simples

Ibutilide and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ibutilide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation, with ibutilide as a potent IKr blocker.

Conduite à tenir

Do not combine. Select an alternative antimalarial, and if mefloquine was recently taken, consider its long half-life before giving ibutilide.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ibutilide with Mefloquine?

MediHelp rates the interaction as contraindicated. Ibutilide and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Mefloquine can add to repolarization delay, so the combination increases the risk of life-threatening arrhythmia.

How serious is the interaction between Ibutilide and Mefloquine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Select an alternative antimalarial, and if mefloquine was recently taken, consider its long half-life before giving ibutilide.

What other medicines interact with Mefloquine?

MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Levoketoconazole. The full list is on the Mefloquine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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