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Interactions médicamenteuses

Amiodarone + Ibutilide

Gravité: Contre-indiquée

Amiodarone and Ibutilide: contraindicated interaction.

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Résumé

Both are class III antiarrhythmics that prolong repolarization. Together they raise the risk of prolonged refractoriness, marked QT prolongation and torsades de pointes.

Ce que signifie cette interaction, en termes simples

Amiodarone and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Ibutilide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive blockade of cardiac potassium channels causing QT prolongation.

Conduite à tenir

Do not give ibutilide to patients on amiodarone, nor other class III agents during or soon after the infusion. Use electrical cardioversion or another option.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Ibutilide?

MediHelp rates the interaction as contraindicated. Amiodarone and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class III antiarrhythmics that prolong repolarization. Together they raise the risk of prolonged refractoriness, marked QT prolongation and torsades de pointes.

How serious is the interaction between Amiodarone and Ibutilide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ibutilide to patients on amiodarone, nor other class III agents during or soon after the infusion. Use electrical cardioversion or another option.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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