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Interactions médicamenteuses

Idelalisib + Tolvaptan

Gravité: Contre-indiquée

Idelalisib and Tolvaptan: contraindicated interaction.

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Résumé

Idelalisib is a strong CYP3A inhibitor and is expected to markedly increase tolvaptan exposure. Strong CYP3A inhibitors are contraindicated with tolvaptan because of the risk of excessive aquaresis and overly rapid sodium correction.

Ce que signifie cette interaction, en termes simples

Idelalisib and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Idelalisib belongs to Oncology; Tolvaptan belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Idelalisib strongly inhibits CYP3A4, greatly reducing tolvaptan clearance.

Conduite à tenir

Do not combine; use an alternative to one of the drugs. If idelalisib is essential, withhold tolvaptan.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Idelalisib with Tolvaptan?

MediHelp rates the interaction as contraindicated. Idelalisib and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and is expected to markedly increase tolvaptan exposure. Strong CYP3A inhibitors are contraindicated with tolvaptan because of the risk of excessive aquaresis and overly rapid sodium correction.

How serious is the interaction between Idelalisib and Tolvaptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative to one of the drugs. If idelalisib is essential, withhold tolvaptan.

What other medicines interact with Tolvaptan?

MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.

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