Interactions médicamenteuses
Influenza virus vaccine quadrivalent intranasal + Oxaliplatin
Gravité: Contre-indiquée
Influenza virus vaccine quadrivalent intranasal and Oxaliplatin: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
The live attenuated intranasal influenza vaccine may replicate in patients immunosuppressed by oxaliplatin and cause influenza illness, with a reduced protective response.
Ce que signifie cette interaction, en termes simples
Influenza virus vaccine quadrivalent intranasal and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.
Conduite à tenir
Use an inactivated injectable influenza vaccine instead during oxaliplatin therapy.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Oxaliplatin 5 mg/ml concentrate for solution for infusion - SmPC sections 4.3/4.5 (class statement: live or live attenuated vaccines; "Vaccination with live or live attenuated vaccines should be avoided in patients receiving oxaliplatin (see section 4.4).") — electronic medicines compendium (UK SmPC)
Autres interactions de Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contre-indiquée
- Bcg vaccine live + Oxaliplatin Contre-indiquée
- Measles mumps and rubella vaccine live + Oxaliplatin Contre-indiquée
- Measles mumps and rubella vaccine + Oxaliplatin Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contre-indiquée
- Measles vaccine + Oxaliplatin Contre-indiquée
Questions fréquentes
Can I take Influenza virus vaccine quadrivalent intranasal with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live attenuated intranasal influenza vaccine may replicate in patients immunosuppressed by oxaliplatin and cause influenza illness, with a reduced protective response.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead during oxaliplatin therapy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine live. The full list is on the Oxaliplatin page.
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