Interactions médicamenteuses
Measles mumps and rubella vaccine + Oxaliplatin
Gravité: Contre-indiquée
Measles mumps and rubella vaccine and Oxaliplatin: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Oxaliplatin-based chemotherapy causes myelosuppression and immune suppression, so the response to the live vaccine may be reduced. Replication of the vaccine viruses may be uncontrolled, which can cause serious vaccine-strain disease.
Ce que signifie cette interaction, en termes simples
Measles mumps and rubella vaccine and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Oxaliplatin belongs to Oncology.
Pourquoi elle survient
Cytotoxic chemotherapy suppresses immune function, which blunts vaccine response and permits replication of live attenuated virus.
Conduite à tenir
Do not give MMR during chemotherapy; give it at least 2 to 4 weeks before starting if feasible. After completion, delay vaccination for about 3 months and until immune recovery.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Oxaliplatin 5 mg/ml concentrate for solution for infusion - SmPC sections 4.3/4.5 (class statement: live or live attenuated vaccines; "Vaccination with live or live attenuated vaccines should be avoided in patients receiving oxaliplatin (see section 4.4).") — electronic medicines compendium (UK SmPC)
Autres interactions de Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contre-indiquée
- Anakinra + Measles mumps and rubella vaccine Contre-indiquée
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contre-indiquée
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Basiliximab + Measles mumps and rubella vaccine Contre-indiquée
Autres interactions de Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contre-indiquée
- Bcg vaccine live + Oxaliplatin Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contre-indiquée
- Measles mumps and rubella vaccine live + Oxaliplatin Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contre-indiquée
- Measles vaccine + Oxaliplatin Contre-indiquée
Questions fréquentes
Can I take Measles mumps and rubella vaccine with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxaliplatin-based chemotherapy causes myelosuppression and immune suppression, so the response to the live vaccine may be reduced. Replication of the vaccine viruses may be uncontrolled, which can cause serious vaccine-strain disease.
How serious is the interaction between Measles mumps and rubella vaccine and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR during chemotherapy; give it at least 2 to 4 weeks before starting if feasible. After completion, delay vaccination for about 3 months and until immune recovery.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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