Interactions médicamenteuses
Measles mumps rubella and varicella vaccine live + Oxaliplatin
Gravité: Contre-indiquée
Measles mumps rubella and varicella vaccine live and Oxaliplatin: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.
Ce que signifie cette interaction, en termes simples
Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.
Conduite à tenir
Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Oxaliplatin 5 mg/ml concentrate for solution for infusion - SmPC sections 4.3/4.5 (class statement: live or live attenuated vaccines; "Vaccination with live or live attenuated vaccines should be avoided in patients receiving oxaliplatin (see section 4.4).") — electronic medicines compendium (UK SmPC)
Autres interactions de Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contre-indiquée
- Bcg vaccine live + Oxaliplatin Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contre-indiquée
- Measles mumps and rubella vaccine live + Oxaliplatin Contre-indiquée
- Measles mumps and rubella vaccine + Oxaliplatin Contre-indiquée
- Measles vaccine + Oxaliplatin Contre-indiquée
Questions fréquentes
Can I take Measles mumps rubella and varicella vaccine live with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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