Interactions médicamenteuses
Insulin degludec / insulin aspart + Megestrol
Gravité: Modérée
Insulin degludec / insulin aspart and Megestrol: moderate interaction.
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Résumé
Megestrol has glucocorticoid-like activity and can raise blood glucose and worsen insulin resistance. Patients on insulin may therefore need higher doses to maintain glycemic control. Hyperglycemia may emerge or worsen during therapy.
Ce que signifie cette interaction, en termes simples
Insulin degludec / insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Pharmacodynamic antagonism through glucocorticoid-like effects of megestrol causing insulin resistance and reduced glucose tolerance.
Conduite à tenir
Monitor blood glucose more frequently when megestrol is started, changed or stopped. Titrate insulin doses, and reduce them again after megestrol is withdrawn.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Megestrol
- Dofetilide + Megestrol Contre-indiquée
- Insulin degludec-insulin aspart + Megestrol Modérée
- Insulin degludec-liraglutide + Megestrol Modérée
- Insulin degludec + Megestrol Modérée
- Insulin inhaled + Megestrol Modérée
- Mavacamten + Megestrol Modérée
Questions fréquentes
Can I take Insulin degludec / insulin aspart with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can raise blood glucose and worsen insulin resistance. Patients on insulin may therefore need higher doses to maintain glycemic control. Hyperglycemia may emerge or worsen during therapy.
How serious is the interaction between Insulin degludec / insulin aspart and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when megestrol is started, changed or stopped. Titrate insulin doses, and reduce them again after megestrol is withdrawn.
What other medicines interact with Megestrol?
MediHelp also lists interactions of Megestrol with, for example, Dofetilide, Insulin degludec-insulin aspart, Insulin degludec-liraglutide. The full list is on the Megestrol page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
