Interactions médicamenteuses
Insulin degludec-insulin aspart + Megestrol
Gravité: Modérée
Insulin degludec-insulin aspart and Megestrol: moderate interaction.
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Résumé
Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
Ce que signifie cette interaction, en termes simples
Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Megestrol belongs to Oncology.
Pourquoi elle survient
Progestogen with glucocorticoid activity that induces insulin resistance, opposing insulin action.
Conduite à tenir
Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Majeure
- Clozapine + Insulin degludec-insulin aspart Majeure
- Diazoxide + Insulin degludec-insulin aspart Majeure
- Ethanol + Insulin degludec-insulin aspart Majeure
- Insulin degludec-insulin aspart + Mecasermin Majeure
- Insulin degludec-insulin aspart + Pioglitazone Majeure
Autres interactions de Megestrol
- Dofetilide + Megestrol Contre-indiquée
- Insulin degludec / insulin aspart + Megestrol Modérée
- Insulin degludec-liraglutide + Megestrol Modérée
- Insulin degludec + Megestrol Modérée
- Insulin inhaled + Megestrol Modérée
- Mavacamten + Megestrol Modérée
Questions fréquentes
Can I take Insulin degludec-insulin aspart with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
How serious is the interaction between Insulin degludec-insulin aspart and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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