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Interactions médicamenteuses

Isosorbide dinitrate + Riociguat

Gravité: Contre-indiquée

Isosorbide dinitrate and Riociguat: contraindicated interaction.

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Résumé

Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.

Ce que signifie cette interaction, en termes simples

Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isosorbide dinitrate belongs to Cardiovascular; Riociguat belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Nitrates release nitric oxide while riociguat stimulates soluble guanylate cyclase, producing additive cGMP-mediated vasodilation.

Conduite à tenir

Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isosorbide dinitrate with Riociguat?

MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.

How serious is the interaction between Isosorbide dinitrate and Riociguat?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.

What other medicines interact with Isosorbide dinitrate?

MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Isosorbide dinitrate page.

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