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Interactions médicamenteuses

Isosorbide dinitrate + Sildenafil

Gravité: Contre-indiquée

Isosorbide dinitrate and Sildenafil: contraindicated interaction.

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Résumé

Sildenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.

Ce que signifie cette interaction, en termes simples

Isosorbide dinitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isosorbide dinitrate belongs to Cardiovascular; Sildenafil belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

PDE5 inhibition potentiates nitrate-induced cGMP vasodilation

Conduite à tenir

Contraindicated; do not give a nitrate within 24 hours of sildenafil, and use an alternative if both are required.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isosorbide dinitrate with Sildenafil?

MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sildenafil inhibits PDE5 and isosorbide dinitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.

How serious is the interaction between Isosorbide dinitrate and Sildenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of sildenafil, and use an alternative if both are required.

What other medicines interact with Sildenafil?

MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.

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