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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Riociguat + Tadalafil

Gravité: Contre-indiquée

Riociguat and Tadalafil: contraindicated interaction.

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Résumé

Riociguat combined with a PDE5 inhibitor such as tadalafil produces additive systemic vasodilation and symptomatic hypotension. In a pulmonary hypertension trial this combination showed no favorable benefit and raised safety concerns, and labeling prohibits it.

Ce que signifie cette interaction, en termes simples

Riociguat and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Riociguat belongs to Cardiovascular; Tadalafil belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

Riociguat stimulates soluble guanylate cyclase to produce cGMP while tadalafil prevents its breakdown, causing additive vasodilation.

Conduite à tenir

Do not coadminister; choose one agent. When switching, follow labeled washout intervals between the drugs.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Riociguat with Tadalafil?

MediHelp rates the interaction as contraindicated. Riociguat and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat combined with a PDE5 inhibitor such as tadalafil produces additive systemic vasodilation and symptomatic hypotension. In a pulmonary hypertension trial this combination showed no favorable benefit and raised safety concerns, and labeling prohibits it.

How serious is the interaction between Riociguat and Tadalafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose one agent. When switching, follow labeled washout intervals between the drugs.

What other medicines interact with Tadalafil?

MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.

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