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Interactions médicamenteuses

Isocarboxazid + Methadone

Gravité: Contre-indiquée

Isocarboxazid and Methadone: contraindicated interaction.

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Résumé

Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.

Ce que signifie cette interaction, en termes simples

Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Methadone belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition combined with methadone's serotonergic activity may precipitate serotonin syndrome, plus additive CNS depression.

Conduite à tenir

Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isocarboxazid with Methadone?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.

How serious is the interaction between Isocarboxazid and Methadone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.

What other medicines interact with Methadone?

MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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