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Interactions médicamenteuses

Levothyroxine + Raloxifene

Gravité: Modérée

Levothyroxine and Raloxifene: moderate interaction.

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Résumé

Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.

Ce que signifie cette interaction, en termes simples

Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Levothyroxine belongs to Endocrine; Raloxifene belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Raloxifene may bind levothyroxine in the gut or otherwise impair its gastrointestinal absorption.

Conduite à tenir

Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Levothyroxine with Raloxifene?

MediHelp rates the interaction as moderate. Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.

How serious is the interaction between Levothyroxine and Raloxifene?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.

What other medicines interact with Raloxifene?

MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Ospemifene, Apalutamide. The full list is on the Raloxifene page.

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