Drug interactions
Levothyroxine + Raloxifene
Severity: Moderate
Levothyroxine and Raloxifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.
What this interaction means in plain words
Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Raloxifene belongs to Endocrine.
Why it happens
Raloxifene may bind levothyroxine in the gut or otherwise impair its gastrointestinal absorption.
What to do
Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Raloxifene
- Cholestyramine + Raloxifene Major
- Ospemifene + Raloxifene Major
- Apalutamide + Raloxifene Moderate
- Famciclovir + Raloxifene Minor
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Raloxifene?
MediHelp rates the interaction as moderate. Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.
How serious is the interaction between Levothyroxine and Raloxifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Ospemifene, Apalutamide. The full list is on the Raloxifene page.
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