Drug interactions
Levothyroxine + Teduglutide
Severity: Moderate
Levothyroxine and Teduglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.
What this interaction means in plain words
Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Teduglutide belongs to Endocrine.
Why it happens
Teduglutide has intestinotrophic effects that enhance gastrointestinal absorption of orally administered drugs.
What to do
Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
Frequently asked questions
Can I take Levothyroxine with Teduglutide?
MediHelp rates the interaction as moderate. Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.
How serious is the interaction between Levothyroxine and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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