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Interactions médicamenteuses

Lincomycin + Rapacuronium

Gravité: Majeure

Lincomycin and Rapacuronium: major interaction.

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Résumé

Lincosamide antibiotics have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing blockers. This may prolong paralysis and delay recovery of respiratory function.

Ce que signifie cette interaction, en termes simples

Lincomycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive neuromuscular blockade through presynaptic and postsynaptic effects of lincomycin.

Conduite à tenir

Monitor neuromuscular function with a nerve stimulator and maintain ventilatory support until full recovery. Reduce the neuromuscular blocker dose if needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lincomycin with Rapacuronium?

MediHelp rates the interaction as major. Lincomycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincosamide antibiotics have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing blockers. This may prolong paralysis and delay recovery of respiratory function.

How serious is the interaction between Lincomycin and Rapacuronium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and maintain ventilatory support until full recovery. Reduce the neuromuscular blocker dose if needed.

What other medicines interact with Lincomycin?

MediHelp also lists interactions of Lincomycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Lincomycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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