Interactions médicamenteuses
Lisinopril + Protein a column
Gravité: Contre-indiquée
Lisinopril and Protein a column: contraindicated interaction.
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Résumé
Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
Ce que signifie cette interaction, en termes simples
Lisinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
ACE inhibition reduces bradykinin breakdown, and column-activated bradykinin generation leads to anaphylactoid reactions.
Conduite à tenir
Stop lisinopril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Lisinopril
- Aliskiren + Lisinopril Contre-indiquée
- Lisinopril + Sacubitril / valsartan Contre-indiquée
- Lisinopril + Sacubitril-valsartan Contre-indiquée
- Amifostine + Lisinopril Majeure
- Amiloride + Lisinopril Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Lisinopril Majeure
Questions fréquentes
Can I take Lisinopril with Protein a column?
MediHelp rates the interaction as contraindicated. Lisinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
How serious is the interaction between Lisinopril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lisinopril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Lisinopril page.
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