Interactions médicamenteuses
Lisinopril + Sacubitril / valsartan
Gravité: Contre-indiquée
Lisinopril and Sacubitril / valsartan: contraindicated interaction.
Dernière mise à jour
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Résumé
Combining an ACE inhibitor with sacubitril/valsartan raises the risk of angioedema because both reduce bradykinin breakdown. The combination is contraindicated in labeling.
Ce que signifie cette interaction, en termes simples
Lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Neprilysin inhibition plus ACE inhibition both impair bradykinin degradation, increasing angioedema risk.
Conduite à tenir
Never co-administer; allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and likewise when switching back.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Lisinopril
- Aliskiren + Lisinopril Contre-indiquée
- Lisinopril + Protein a column Contre-indiquée
- Lisinopril + Sacubitril-valsartan Contre-indiquée
- Amifostine + Lisinopril Majeure
- Amiloride + Lisinopril Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Lisinopril Majeure
Questions fréquentes
Can I take Lisinopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an ACE inhibitor with sacubitril/valsartan raises the risk of angioedema because both reduce bradykinin breakdown. The combination is contraindicated in labeling.
How serious is the interaction between Lisinopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never co-administer; allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and likewise when switching back.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril-valsartan. The full list is on the Lisinopril page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
