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Interactions médicamenteuses

Lisinopril + Sacubitril-valsartan

Gravité: Contre-indiquée

Lisinopril and Sacubitril-valsartan: contraindicated interaction.

Dernière mise à jour

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Résumé

Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.

Ce que signifie cette interaction, en termes simples

Lisinopril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lisinopril belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Both neprilysin and ACE degrade bradykinin; inhibiting both increases bradykinin levels.

Conduite à tenir

Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lisinopril with Sacubitril-valsartan?

MediHelp rates the interaction as contraindicated. Lisinopril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.

How serious is the interaction between Lisinopril and Sacubitril-valsartan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.

What other medicines interact with Sacubitril-valsartan?

MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.

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