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Interactions médicamenteuses

Lorlatinib + Rifabutin

Gravité: Contre-indiquée

Lorlatinib and Rifabutin: contraindicated interaction.

Dernière mise à jour

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Résumé

Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.

Ce que signifie cette interaction, en termes simples

Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lorlatinib belongs to Oncology; Rifabutin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

CYP3A4 induction increases lorlatinib metabolism and lowers its plasma concentration.

Conduite à tenir

Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lorlatinib with Rifabutin?

MediHelp rates the interaction as contraindicated. Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.

How serious is the interaction between Lorlatinib and Rifabutin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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